Access this content:
June 3, 2020 / in Scientific Article

Abstract

Background

The use of commercialised forced oscillation techniques to assess impedance in obstructive diseases such as asthma has gained popularity. However, it has yet to be fully established whether resistance and reactance measurements are comparable across different FOT devices.

Methods

We compared two commercially available FOT devices: Impulse Oscillometry System (IOS) and TremoFlo FOT (Thorasys) in a) clinical adult population of healthy controls (n=14), asymptomatic smokers (n=17) and individuals with asthma (n=73) and b) a 3D printed CT-based airway model resistance, as well as a 3 litre standardised volume reactance.

Results

Resistance measurements were higher with FOT compared to IOS, however there was no evidence of systematic bias. In contrast, significant bias was demonstrated with reactance (primarily elastance) measurements across the devices. The TremoFlo device recorded smaller (more negative) reactances at 5Hz and 20Hz (numerically smaller) when compared to IOS. The printed airway resistance and standardised volume reactance confirmed the observations in patients.

Discussion

We have demonstrated that the impulse oscillation system and Tremoflo FOT generate comparable measurements of airways resistance. In contrast, FOT appeared to be more sensitive at probing airway elastance properties when compared to IOS. Our results highlight the need for further standardisation across FOT measurement devices.

The articles include uses of tremoflo products or describes research devices that may not have been cleared by FD
Source

Soares M, Richardson M, Thorpe J, Owers-Bradley J, Siddiqui S. Comparison of Forced and Impulse Oscillometry Measurements: A Clinical Population and Printed Airway Model Study. Sci Rep. 2019;9:2130.

Other resources of interest

May 2, 2022
Novel Measurements of Respiratory System Mechanics Demonstrate Important Features of Donor-Recipient Lung Volume Matching That May Link to Subsequent Chronic Lung Allograft Dysfunction
The effect of matching donor and lung transplant (LTx) recipient lung volumes on LTx outcomes is unknown. The Forced Oscillation Technique (FOT) is a simple measure of the mechanical properties of the respiratory system. We have recently developed novel measures of airway closure using FOT. This study aims to assess the effect of matching donor and recipient lung volumes on respiratory system mechanics using FOT.
May 2, 2022
Effects of Donor Smoking History on Early Post-Transplant Lung Function Measured by Oscillometry
Oscillometry (Osc) is a non-invasive test of respiratory impedance that is sensitive to small airways, a region not well characterized by conventional pulmonary function tests (PFT). It has been shown to detect early COPD prior to changes in PFT. We posit that Osc could identify small airway obstruction post-lung transplant (LTx) and discriminate between lungs from smoking vs non-smoking donors.
May 2, 2022
Calling Time on Spirometry: Unlocking the Silent Zone in Acute Rejection after Lung Transplantation
Lung transplantation is the only effective treatment for patients with end-stage lung disease, yet median survival is only 6 years and significantly shorter than that observed with other solid-organ transplants (1). Acute cellular rejection (ACR) causing graft failure is the major cause of death in the first year, and is also a risk factor for chronic lung allograft dysfunction (CLAD) (2).
May 2, 2022
Novel Measurements of Respiratory System Mechanics Demonstrate Important Features of Donor-Recipient Lung Volume Matching That May Link to Subsequent Chronic Lung Allograft Dysfunction
The effect of matching donor and lung transplant (LTx) recipient lung volumes on LTx outcomes is unknown. The Forced Oscillation Technique (FOT) is a simple measure of the mechanical properties of the respiratory system. We have recently developed novel measures of airway closure using FOT. This study aims to assess the effect of matching donor and recipient lung volumes on respiratory system mechanics using FOT.
May 2, 2022
Effects of Donor Smoking History on Early Post-Transplant Lung Function Measured by Oscillometry
Oscillometry (Osc) is a non-invasive test of respiratory impedance that is sensitive to small airways, a region not well characterized by conventional pulmonary function tests (PFT). It has been shown to detect early COPD prior to changes in PFT. We posit that Osc could identify small airway obstruction post-lung transplant (LTx) and discriminate between lungs from smoking vs non-smoking donors.
May 2, 2022
Calling Time on Spirometry: Unlocking the Silent Zone in Acute Rejection after Lung Transplantation
Lung transplantation is the only effective treatment for patients with end-stage lung disease, yet median survival is only 6 years and significantly shorter than that observed with other solid-organ transplants (1). Acute cellular rejection (ACR) causing graft failure is the major cause of death in the first year, and is also a risk factor for chronic lung allograft dysfunction (CLAD) (2).
Contact us
Interested in THORASYS products? Contact us to get a personalized quote.
Let us know how we can assist. We would love to hear from you.
Form submitted successfully!
We'll get back to you shortly.